King's College Hospital, London.
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SERIAL CHANGES IN 24 HOUR CREATININE CLEARANCE DURING NORMAL MENSTRUAL CYCLES AND THE FIRST TRIMESTER OF PREGNANCY
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1981.tb00930.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 88, Issue 1, pages 10–17, January 1981
Additional Information
How to Cite
Davison, J. M. and Noble, M. C. B. (1981), SERIAL CHANGES IN 24 HOUR CREATININE CLEARANCE DURING NORMAL MENSTRUAL CYCLES AND THE FIRST TRIMESTER OF PREGNANCY. BJOG: An International Journal of Obstetrics & Gynaecology, 88: 10–17. doi: 10.1111/j.1471-0528.1981.tb00930.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Received May 12, 1980/Accepted June 6, 1980
- Abstract
- References
- Cited By
Summary
Serial changes in 24-hour creatinine clearance were determined in 11 women during several menstrual cycles before conception, the conceptional cycle and the first trimester of pregnancy. During the menstrual cycle, a 20 per cent mean increase occurred between the week of menstruation and the late luteal phase. Following conception, this increase continued such that a 45 per cent mean increase was evident by the ninth week of gestation. In two women who aborted spontaneously, the change in 24-hour creatinine clearance in early pregnancy was not as great nor as sustained, this feature being apparent at least three weeks before any clinical abnormality. Possible reasons for the changes in glomerular filtration rate in early pregnancy and its clinical implications are discussed.