School of Pharmacy, Sunderland Polytechnic, Chester Road, Sunderland.
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THE EFFECT OF CARCINOMA OF THE CERVIX ON THE L-LACTATE-NICOTINAMIDE-ADENINEDINUCLEOTIDE OXIDOREDUCTASE ACTIVITY IN VAGINAL ASPIRATES
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1981.tb00934.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 88, Issue 1, pages 36–41, January 1981
Additional Information
How to Cite
Emes, A. V., Latner, A. L., Guthrie, D., Philips, P. R. and Way, S. A. (1981), THE EFFECT OF CARCINOMA OF THE CERVIX ON THE L-LACTATE-NICOTINAMIDE-ADENINEDINUCLEOTIDE OXIDOREDUCTASE ACTIVITY IN VAGINAL ASPIRATES. BJOG: An International Journal of Obstetrics & Gynaecology, 88: 36–41. doi: 10.1111/j.1471-0528.1981.tb00934.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Received May 2, 1980/Accepted July 2, 1980
- Abstract
- References
- Cited By
Summary
Lactate dehydrogenase (L-lactate-NAD+ oxidoreductase; EC 1. 1. 1. 27) has been assayed in saline extracts of vaginal aspirates obtained from patients with carcinoma in situ and from patients with clinically detectable invasive carcinoma of the cervix. Taking premenopausal and postmenopausal patients separately, significant differences were found between the aspirate lactate dehydrogenase activities obtained from patients with carcinoma in situ and the activities obtained from patients with invasive carcinoma; generally higher activities were obtained from the latter. With the exception of postmenopausal patients with carcinoma in situ, aspirate enzyme activities obtained from both groups of patients were significantly different from those obtained from normal women. Significantly higher lactate dehydrogenase activity was found in aspirates from patients for whom histology showed the presence of an adenocarcinoma or certain highly malignant cell types. Treatment by radium insertion usually resulted in a fall in total lactate dehydrogenase activity. Significant differences between patient groups were found for the proportions of single lactate dehydrogenase isoenzymes in a few instances but no significant difference in overall isoenzyme distribution was found.