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PLACENTAL TRANSFER OF CEFUROXIME
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1981.tb00958.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 88, Issue 2, pages 141–145, February 1981
Additional Information
How to Cite
Craft, I., Mullinger, B. M. and Kennedy, M. R. K. (1981), PLACENTAL TRANSFER OF CEFUROXIME. BJOG: An International Journal of Obstetrics & Gynaecology, 88: 141–145. doi: 10.1111/j.1471-0528.1981.tb00958.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Received September 5, 1979/Accepted August 6, 1980
- Abstract
- References
- Cited By
Summary
The transfer of cefuroxime across the placenta was studied in 10 women in labour and 12 women being delivered by Caesarean section. Following a single intramuscular injection of 750 mg cefuroxime, high antibiotic concentrations were found in the amniotic fluid in women in labour; the peak concentration of 18 mg/1 was achieved after five hours. Therapeutic concentrations of cefuroxime were present in umbilical vein serum for up to eight hours after injection. A similar pharmacokinetic picture was observed in the women undergoing Caesarean section although in the limited time interval (up to four hours) between injection and delivery the amniotic fluid levels of cefuroxime achieved were lower. Cefuroxime appears to cross the placenta well to produce effective concentrations in fetal blood and amniotic fluid.