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PROSTACYCLIN-LIKE AND KALLIKREIN ACTIVITY OF AMNIOTIC FLUID IN PRE-ECLAMPSIA
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1981.tb01200.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 88, Issue 12, pages 1217–1222, December 1981
Additional Information
How to Cite
Bodzenta, A., Thomson, J. M., Poller, L., Burslem, R. W. and Wilcox, F. L. (1981), PROSTACYCLIN-LIKE AND KALLIKREIN ACTIVITY OF AMNIOTIC FLUID IN PRE-ECLAMPSIA. BJOG: An International Journal of Obstetrics & Gynaecology, 88: 1217–1222. doi: 10.1111/j.1471-0528.1981.tb01200.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Received March 4, 1981/Accepted August 5, 1981
- Abstract
- References
- Cited By
Summary
Amniotic fluid from patients with pre-eclampsia was compared with samples obtained from normotensive controls with respect to the inhibiting effect on platelet aggregation (PGI2-like activity) and activating effect on the plasma kallikrein assay and Russell's viper venom test. After 39 weeks gestation, amniotic fluid from pre-eclamptic patients showed significantly less PGI2-like activity (p <0.01) and significantly lower kallikrein levels (p <0.01) than that from normotensive controls. The study suggests that the biosynthesis and release of PGI2-like activity and kallikrein may be impaired in pre-eclampsia. In view of the association of pre-eclampsia with intravascular clotting, the highly significant reduction of PGI2-like activity seems important and appears to warrant a clinical trial of prostacyclin administration in this disorder.