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MATERNAL SERUM LEVELS OF SEX STEROID-BINDING PROTEIN DURING PREGNANCY
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1981.tb01202.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 88, Issue 12, pages 1229–1232, December 1981
Additional Information
How to Cite
Uriel, J., Dupiers, M., Rimbaut, C. and Buffe, D. (1981), MATERNAL SERUM LEVELS OF SEX STEROID-BINDING PROTEIN DURING PREGNANCY. BJOG: An International Journal of Obstetrics & Gynaecology, 88: 1229–1232. doi: 10.1111/j.1471-0528.1981.tb01202.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Received March 3, 1981/Accepted August 13, 1981
- Abstract
- References
- Cited By
Summary
Serum concentrations of sex steroid-binding protein (SBP) were measured by an immunodiffusion technique in a total of 133 samples from 70 healthy pregnant women, 18 puerperal women and 21 non-pregnant women. In 6 individuals, trends of serum SBP were established from multiple samples taken throughout pregnancy. Maternal serum SBP levels had increased significantly above base line values as early as by 10 weeks gestation, and attained a plateau between 25 and 30 weeks, at which time mean values were about 10-fold higher than the normal non-pregnant range, the levels then declined slightly twoards term. Parallel measurements of dihydrotestosterone-binding capacity of SBP showed a good correlation between SBP content and biological activity. Six abnormal pregnancies were encountered in the present study, and in five of them the molar ratios of bound hormone to SBP concentration were much lower than the normal value, suggesting a reduced binding capacity of the protein for the hormone.