Senior Registrar, Dudley Road Hospital, Birmingham.
THE EFFECT OF MENOPAUSAL STATUS AND SEQUENTIAL MESTRANOL AND NORETHISTERONE ON SERUM BIOCHEMICAL PROFILES
Article first published online: 23 AUG 2005
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 88, Issue 8, pages 853–858, August 1981
How to Cite
Moore, B., Paterson, M. E. L., Sturdee, D. W. and Whitehead, T. P. (1981), THE EFFECT OF MENOPAUSAL STATUS AND SEQUENTIAL MESTRANOL AND NORETHISTERONE ON SERUM BIOCHEMICAL PROFILES. BJOG: An International Journal of Obstetrics & Gynaecology, 88: 853–858. doi: 10.1111/j.1471-0528.1981.tb01313.x
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Received July 14, 1980/Accepted March 15, 1981.
Serum biochemical profiles were compared in matched groups of premenopausal and postmenopausal women. Significantly higher concentrations of sodium, urea, calcium, albumin and alkaline phosphatase were found in the postmenopausal group. In the postmenopausal group, following treatment with sequential mestranol and norethisterone, significant reductions were recorded in the concentrations of sodium, urea, calcium, albumin, alkaline phosphatase and glucose and significant increases were recorded in the concentration of globulin and in body weight. The findings suggest that haemoconcentration may take place after the menopause and that this effect may be modified by hormone treatment. No adverse effect on liver function was noted following the hormone treatment.