THE EFFECT OF MENOPAUSAL STATUS AND SEQUENTIAL MESTRANOL AND NORETHISTERONE ON SERUM BIOCHEMICAL PROFILES

Authors

  • B. Moore,

    Senior Registrar
    1. University Department of Obstetrics and Gynaecology The Birmingham and Midland Hospital for Women Showell Green Lane, Birmingham 11
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    • *

      Senior Registrar, Dudley Road Hospital, Birmingham.

  • M. E. L. Paterson,

    Research Fellow
    1. University Department of Obstetrics and Gynaecology The Birmingham and Midland Hospital for Women Showell Green Lane, Birmingham 11
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    • Senior Registrar, The Women's Hospital at Leeds, Leeds.

  • D. W. Sturdee,

    Research Fellow
    1. University Department of Obstetrics and Gynaecology The Birmingham and Midland Hospital for Women Showell Green Lane, Birmingham 11
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    • Consultant Gynaecologist, Solihull Hospital, W. Midlands.

  • T. P. Whitehead

    Professor
    1. Wolfson Research Laboratories Queen Elizabeth Medical Centre, Birmingham 15
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Summary

Serum biochemical profiles were compared in matched groups of premenopausal and postmenopausal women. Significantly higher concentrations of sodium, urea, calcium, albumin and alkaline phosphatase were found in the postmenopausal group. In the postmenopausal group, following treatment with sequential mestranol and norethisterone, significant reductions were recorded in the concentrations of sodium, urea, calcium, albumin, alkaline phosphatase and glucose and significant increases were recorded in the concentration of globulin and in body weight. The findings suggest that haemoconcentration may take place after the menopause and that this effect may be modified by hormone treatment. No adverse effect on liver function was noted following the hormone treatment.

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