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PREGNANCY-ASSOCIATED PLASMA PROTEIN-A (PAPP-A) AND hCG IN EARLY PREGNANCY
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1981.tb01683.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 88, Issue 10, pages 973–975, October 1981
Additional Information
How to Cite
Bischof, P., DuBerg, S., Herrmann, W. and Sizonenko, P. C. (1981), PREGNANCY-ASSOCIATED PLASMA PROTEIN-A (PAPP-A) AND hCG IN EARLY PREGNANCY. BJOG: An International Journal of Obstetrics & Gynaecology, 88: 973–975. doi: 10.1111/j.1471-0528.1981.tb01683.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Received April 8, 1981/accepted June 6, 1981
- Abstract
- References
- Cited By
Summary
Pregnancy-associated plasma protein-A (PAPP-A) is a recently described glycoprotein of unknown biological function. The development of a radioimmunoassay enabled us to measure plasma levels of PAPP-A and human chorionic gonadotrophin (hCG) in 12 non-pregnant volunteers and in 159 women in early pregnancy attending the outpatient clinic for legal abortion. PAPP-A but not hCG was measurable in all non-pregnant women. In pregnant patients (with 36 to 86 days of amenorrhea) hCG reached a peak value (163.1–197.6 ng/ml) between the 9th and the 13th week whereas PAPP-A steadily increased throughout this period of pregnancy. Between the 6th and the 13th week after the last menstrual period, levels of PAPP-A increased proportionally more than hCG. This work provides the first evidence of a PAPP-A production in non-pregnant subjects and the very early marked increase of PAPP-A secretion during pregnancy.