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THROMBOCYTOPENIA AND MACROTHROMBOCYTOSIS IN GESTATIONAL HYPERTENSION
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1981.tb01764.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 88, Issue 11, pages 1115–1119, November 1981
Additional Information
How to Cite
Giles, C. and Inglis, T. C. M. (1981), THROMBOCYTOPENIA AND MACROTHROMBOCYTOSIS IN GESTATIONAL HYPERTENSION. BJOG: An International Journal of Obstetrics & Gynaecology, 88: 1115–1119. doi: 10.1111/j.1471-0528.1981.tb01764.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Received April 27, 1981/Accepted July 6, 1981
- Abstract
- References
- Cited By
Summary
The platelet count in 550 patients with gestational hypertension was significantly lower and the mean platelet volume significantly higher than in normal pregnant women. Both the platelet count and volume became increasingly abnormal when hypertension was accompanied by oedema, proteinuria or both, and women with severe pre-eclampsia or eclampsia had the lowest platelet counts and the highest mean platelet volume. The proportion of patients with thrombocytopenia and/or macrothrombocytosis also varied with the severity of the clinical presentation. Fibrinogen degradation products were found mainly in fully developed preeclampsia. These findings confirm the concept of a rapid platelet turnover caused by low-grade disseminated intravascular coagulation in gestational hypertension. The platelet pattern in essential hypertension is similar to that seen in normal pregnancy.