CHLAMYDIA TRACHOMATIS AND HERPES SIMPLEX VIRUS IgA ANTIBODIES IN CERVICAL SECRETIONS OF PATIENTS WITH CERVICAL ATYPIA

  1. Kirsti Kalimo Consultant Dermatologist 1,
  2. P. Terho Assistant 2,
  3. E. Honkonen Assistant Physician 3,
  4. M. Grönroos Docent 3,
  5. P. Halonen Professor 2

Article first published online: 23 AUG 2005

DOI: 10.1111/j.1471-0528.1981.tb01767.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 88, Issue 11, pages 1130–1134, November 1981

Additional Information

How to Cite

Kalimo, K., Terho, P., Honkonen, E., Grönroos, M. and Halonen, P. (1981), CHLAMYDIA TRACHOMATIS AND HERPES SIMPLEX VIRUS IgA ANTIBODIES IN CERVICAL SECRETIONS OF PATIENTS WITH CERVICAL ATYPIA. BJOG: An International Journal of Obstetrics & Gynaecology, 88: 1130–1134. doi: 10.1111/j.1471-0528.1981.tb01767.x

Author Information

  1. 1

    Department of Dermatology and Venereology, University of Turku 20520 Turku 52, Finland

  2. 2

    Department of Virology, University of Turku 20520 Turku 52, Finland

  3. 3

    Department of Obstetrics and Gynaecology, University of Turku 20520 Turku 52, Finland

Publication History

  1. Issue published online: 23 AUG 2005
  2. Article first published online: 23 AUG 2005
  3. Received April 6, 1981/Accepted June 29, 1981

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Summary

The association of Chlamydia trachomatis (CT) and herpes simplex virus (HSV) with malignant or premalignant changes in the cervix uteri was studied by determining immunoglobulin A (IgA) antibodies in the cervical secretions of 28 women with inflammatory, 28 with dysplastic, 7 with malignant changes of the uterine cervix, and 26 healthy controls. In cervical secretions IgA antibodies to CT were found in 24 of 35 (69%) patients with malignant or premalignant changes, in 11 of 28 (39%) with cervicitis and in 3 of 26 (12%) controls. IgA antibodies to HSV were found in 10 of 35 (28%) patients with malignant atypia or dysplasia but in none of the women with cervicitis or the controls. The highest frequency of antibodies was found in the patients with cervical carcinoma. Serum IgA antibodies to CT and HSV were found equally in the patients and the controls. Our results suggest that in patients with cervical atypia, local IgA CT antibody production occurs. Whether this association is aetiological or coincidental can not be concluded from this study.

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