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Summary

During the years 1952–1977, 646 patients with abnormal cervical cytology underwent cone biopsy (595) or ring biopsy of the cervix. The histological diagnoses were invasive carcinoma 20 (3%) microinvasive carcinoma 16 (2%), carcinoma in situ and severe dysplasia 418 (65 %), other dysplasias 149 (23 %). The remainder, 43 (7%) had no demonstrable abnormality. Following biopsy 41 (7%) patients with non-invasive disease had abnormal cytology within a year of biopsy. A further 12 (2%) developed abnormal cytology after one year. These recurrences occurred up to 12 years after the initial treatment, and in one patient invasive squamous carcinoma has developed.