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“LUPUS” ANTICOAGULANT AND INHIBITION OF PROSTACYCLIN FORMATION IN PATIENTS WITH REPEATED ABORTION, INTRAUTERINE GROWTH RETARDATION AND INTRAUTERINE DEATH
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1981.tb02224.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 88, Issue 9, pages 890–894, September 1981
Additional Information
How to Cite
Carreras, L. O., Vermylen, J., Spitz, B. and Van Assche, A. (1981), “LUPUS” ANTICOAGULANT AND INHIBITION OF PROSTACYCLIN FORMATION IN PATIENTS WITH REPEATED ABORTION, INTRAUTERINE GROWTH RETARDATION AND INTRAUTERINE DEATH. BJOG: An International Journal of Obstetrics & Gynaecology, 88: 890–894. doi: 10.1111/j.1471-0528.1981.tb02224.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Received November 14,1980/Accepted March 11,1981
- Abstract
- References
- Cited By
Summary
We discovered a‘lupus’ anticoagulant in 2 out of 24 women with a history of repeated abortions, intrauterine growth retardation and intrauterine death of unknown origin. The‘lupus’ anticoagulant was detected by an abnormal dilute tissue thromboplastin assay (prothrombin time performed with dilute thromboplastin). The production of prostacyclin by fresh or exhausted rings of rat aorta was decreased by the plasma of one of these two patients with a‘lupus’ anticoagulant. In view of the increasing evidence for a physiological role of prostacyclin in pregnancy and fetal life, we suggest that an inhibition of prostacyclin production could compromise fetal outcome.