Senior Registrar, Hospital for Women at Leeds, Jackson Avenue, Leeds 8, UK.
A randomized double-blind cross-over trial into the effect of norethisterone on climacteric symptoms and biochemical profiles
Article first published online: 23 AUG 2005
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 89, Issue 6, pages 464–472, June 1982
How to Cite
PATERSON, M. E. L. (1982), A randomized double-blind cross-over trial into the effect of norethisterone on climacteric symptoms and biochemical profiles. BJOG: An International Journal of Obstetrics & Gynaecology, 89: 464–472. doi: 10.1111/j.1471-0528.1982.tb03638.x
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Received 23 July 1981 Accepted 3 December 1981
Summary. A randomized double-blind cross-over study into the effect of northisterone on climacteric symptoms was performed on 23 postmenopausal women. Active therapy resulted in a significant reduction in the number and severity of hot flushes and night sweats. There was also a slight improvement in memory, insomnia and lack of energy but the other climacteric symptoms were not consistently altered. Side effects were minimal. There was a significant reduction in serum calcium, alkaline phosphatase, cholesterol, triglycerides, follicle-stimulating hormone and luteinizing hormone levels. There was a variable effect on serum creatinine and urea but there was no significant alteration in the other biochemical profiles, liver-function tests, weight or blood pressure.