Cervical wart virus infection, intraepithelial neoplasia and carcinoma; an immunohistological study using a panel of monoclonal antibodies

  1. HUGH B. MORRIS Clinical Lecturer1,†,
  2. KEVIN C. GATTER Wellcome Research Fellow1,*,
  3. KAREN PULFORD Research Assistant1,
  4. PETER HAYNES Clinical Lecturer2,
  5. MARK CHARNOCK Consultant Gynaecologist2,
  6. J. TAYLOR-PAPADIMITRIOU Senior Scientist3,
  7. E. B. LANE Senior Scientist3,
  8. DAVID Y. MASON University Lecturer Nuffield1

Article first published online: 23 AUG 2005

DOI: 10.1111/j.1471-0528.1983.tb06447.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 90, Issue 11, pages 1069–1081, November 1983

Additional Information

How to Cite

MORRIS, H. B., GATTER, K. C., PULFORD, K., HAYNES, P., CHARNOCK, M., TAYLOR-PAPADIMITRIOU, J., LANE, E. B. and MASON, D. Y. (1983), Cervical wart virus infection, intraepithelial neoplasia and carcinoma; an immunohistological study using a panel of monoclonal antibodies. BJOG: An International Journal of Obstetrics & Gynaecology, 90: 1069–1081. doi: 10.1111/j.1471-0528.1983.tb06447.x

Author Information

  1. 1

    Department of Histopathology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU

  2. 2

    Departments of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU

  3. 3

    Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC1

  1. †

    Department of Pathology, University of Cape Town Medical School, Anzio Road, Observatory, Cape Town, South Africa.

* *Correspondence to Dr K. C. Gatter.

Publication History

  1. Issue published online: 23 AUG 2005
  2. Article first published online: 23 AUG 2005
  3. Received 26 November 1982 Accepted 4 March 1983

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Summary. The pattern of epithelial antigen expression has been examined in normal and disordered cervical squamous epithelium using immunohistological methods and a range of monoclonal antibodies. It was demonstrated that wart virus infection (WVI) is associated with disordered staining for a keratin-associated component and for HLA-DR antigen. Furthermore, wart-infected epithelium shows strong labelling for carcinoem-bryonic antigen (CEA) and for human milk fat globule antigens 1 and 2 (HMFG1 and 2). In addition these antigens (CEA, HMFG1 and 2) are also expressed in mixed WVI and cervical intraepithelial neoplasia (CIN), CIN III and in carcinoma. While these findings do not allow immunohistological discrimination between non-neoplastic and neoplastic cervical epithelia, they do provide support for the view that cellular proliferation of the type induced by papilloma virus may represent an initiator stage in the process of neoplastic transformation.

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