1471-0528/asset/BJO_left.gif?v=1&s=0fb87361cdb6be25fdf05019eed6d47f5143f610)
1471-0528/asset/olbannerright.gif?v=1&s=3892ef16ff18d6834c302faf85268a49f5fc588f)
Primary dysmenorrhoea: the importance of both prostaglandins E2 and F2α
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1983.tb06460.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 90, Issue 12, pages 1135–1140, December 1983
Additional Information
How to Cite
LUMSDEN, M. A., KELLY, R. W. and BAIRD, D. T. (1983), Primary dysmenorrhoea: the importance of both prostaglandins E2 and F2α. BJOG: An International Journal of Obstetrics & Gynaecology, 90: 1135–1140. doi: 10.1111/j.1471-0528.1983.tb06460.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Received 9 February 1983 Accepted 5 May 1983
- Abstract
- References
- Cited By
Summary. Menstrual fluid was collected in a contraceptive diaphragm from 16 women with primary dysmenorrhoea and 12 matched control subjects without dysmenorrhoea. Prostaglandins F2α (PGF2α), E2 (PGE2) and 6-oxo-prostaglandin F1α (6-oxo-PGFlα) were extracted and measured using gas-chromatography: mass spectrometry (GC:MS). The concentrations of both PGF2α and PGE2 were higher on days 1 and 2 in the dysmenorrhoea group than in the control group and the concentration of PGF2α was higher on day 1 than on day 2 in the dysmenorrhoea group. The concentrations of 6-oxo-PGF1α (the stable metabolite of PGI2) were low in both groups. These results confirm suggestions that PGF2α is important in the aetiology of dysmenorrhoea and also indicate that PGE2 may be involved.