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Summary. The blood levels of α2-macroglobulin, α1-antitrypsin, CT inactivator, antithrombin III and α2-antiplasmin were measured in 18 primigravidae with moderate or severe pre-eclampsia and in 18 gestation-matched primigravidae with uncomplicated pregnancy. The mean levels of the proteinase inhibitors did not differ between the pre-eclampsia and uncomplicated pregnancy groups.