Effect of vacuum curettage on the concentrations of plasma 6-keto-prostaglandin Flα and serum thromboxane B2

  1. O. YLIKORKALA,
  2. U.-M. MÄKILÄ,
  3. L. VIINIKKA

Article first published online: 23 AUG 2005

DOI: 10.1111/j.1471-0528.1983.tb08619.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 90, Issue 3, pages 251–254, March 1983

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How to Cite

YLIKORKALA, O., MÄKILÄ, U.-M. and VIINIKKA, L. (1983), Effect of vacuum curettage on the concentrations of plasma 6-keto-prostaglandin Flα and serum thromboxane B2. BJOG: An International Journal of Obstetrics & Gynaecology, 90: 251–254. doi: 10.1111/j.1471-0528.1983.tb08619.x

Author Information

  1. Departments of Obstetrics and Gynaecology and Clinical Chemistry, University of Oulu, Oulu, Finland

Publication History

  1. Issue published online: 23 AUG 2005
  2. Article first published online: 23 AUG 2005

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Summary. Serial plasma samples collected before and after vacuum curettage followed by methylergometrine injection in 10 women were assayed for 6-keto-prostaglandin Flα (6-keto-PGF1α). The mean 6-keto-PGFlα concentration was 97.2 (SE 8.8) pg/ml before cervical dilatation. The concentration rose to 128.2 (SE 13.5) pg/ml (P < 0.10) immediately and to 133.3 (SE 17.8) pg/ml (P < 0.05) 1 h after curettage and returned to the initial value within 5 h. Neither methylergometrine nor anaesthesia, nor non-gynaecological surgery, caused changes in the level of plasma 6-keto-PGFlα. The capacity of the platelets to produce thromboxane A2 during spontaneous clotting of blood did not change during vacuum curettage, anaesthesia and non-gynaecological surgery, nor after methylergometrine. The evidence suggests that the pregnant myometrium and/or intrauterine tissues capable of generating prostacyclin (PGI2) in vitro may release PG12 also in vivo.

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