Value of Schwangerschaftsprotein 1 (SP1) and pregnancy-associated plasma protein-A (PAPP-A) in the clinical management of threatened abortion

Authors

  • GORDON M. MASSON,

    Senior Lecturer
    1. Department of Human Reproduction and Obstetrics, University of Southampton, Princess Anne Hospital, Southampton SO9 4 HA, UK
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  • FREDERICK ANTHONY,

    Biochemist
    1. Department of Human Reproduction and Obstetrics, University of Southampton, Princess Anne Hospital, Southampton SO9 4 HA, UK
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  • MARY S. WILSON

    Medical Student
    1. Department of Human Reproduction and Obstetrics, University of Southampton, Princess Anne Hospital, Southampton SO9 4 HA, UK
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Abstract

Summary. Pregnancy-associated plasma protein-A (PAPP-A) and Schwangerschaftsprotein 1 (SP1) levels were measured in single serum samples from 60 patients admitted with vaginal bleeding in the first 14 weeks of pregnancy. When based on ultrasound diagnoses the prediction of non-viability (the predictive value) was 97% for SP1 and 84% for PAPP-A. Whereas the prediction of viability (above –2SD of the normal range) with SP1 was 88% the value with PAPP-A was only 57%; the poorer result obtained with PAPP-A probably reflects its longer half-life. Pregnancy outcome is not related to the duration of bleeding.

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