Lymphocyte subsets in normal and pre-eclamptic pregnancies

  1. M. P. MOORE Medical Research Council of New Zealand, Overseas Research Fellow1,
  2. N. P. CARTER Senior Scientific Officer2,
  3. W. G. REDMAN Lecturer in Obstetric Medicine1

Article first published online: 23 AUG 2005

DOI: 10.1111/j.1471-0528.1983.tb08918.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 90, Issue 4, pages 326–331, April 1983

Additional Information

How to Cite

MOORE, M. P., CARTER, N. P. and REDMAN, W. G. (1983), Lymphocyte subsets in normal and pre-eclamptic pregnancies. BJOG: An International Journal of Obstetrics & Gynaecology, 90: 326–331. doi: 10.1111/j.1471-0528.1983.tb08918.x

Author Information

  1. 1

    Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK

  2. 2

    Nuffield Department of Obstetrics and Surgery, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK

Publication History

  1. Issue published online: 23 AUG 2005
  2. Article first published online: 23 AUG 2005
  3. Received 6 July 1982 Accepted S October 1982

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Summary. Peripheral blood lymphocyte subsets in normal and preeclamptic pregnancies have been studied by using the monoclonal antibodies OKT3 (T cells), OKT4 (helper/inducer T cells) and OKT8 (suppressor/cytotoxic T cells). In addition the numbers of mononuclear cells bearing la and monocyte antigens have been assessed by using the monoclonal antibodies OKIal and OKM1. No significant differences were found between 10 normal pregnant and 10 non-pregnant subjects. Ten preeclamptic patients were studied and showed an increase in OKT4-positive helper cells. This was significant in terms of percentage of mononuclear cells but not the absolute numbers or the helper/suppressor (OKT4/OKT8) ratio.

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