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Fetal growth achievement and elevated maternal serum α-fetoprotein
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1983.tb08939.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 90, Issue 5, pages 433–436, May 1983
Additional Information
How to Cite
PURDIE, D. W., YOUNG, J. L., GUTHRIE, K. A. and PICTON, C. E. (1983), Fetal growth achievement and elevated maternal serum α-fetoprotein. BJOG: An International Journal of Obstetrics & Gynaecology, 90: 433–436. doi: 10.1111/j.1471-0528.1983.tb08939.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Received 21 May 1982 Accepted 20, December 1982
- Abstract
- References
- Cited By
Summary. Maternal serum α-fetoprotein (AFP) was measured by radio-immunoassay in 7223 unselected patients between 16 and 20 weeks gestation. In 141 patients an elevated AFP level (.2.5 multiples of the median for gestation) was found in the absence of a primary cause. When the birthweights of the 137 liveborn infants were corrected for maternal height and weight, sex and birth rank, 37 (27%) fell below the 10th centile of normal birthweight standards. No excess of premature deliveries was found, but there was a significant association with primiparity. Patients delivered of their second infant showed a significant decrement in mean birthweight when compared with their first-born infants and with a matched control group (normal maternal serum AFP levels). There was a highly significant association between elevated serum AFP and subsequent placental abruption.