Department of Obstetrics, Westminster Hospital, Dean Ryle Street, London SW1P 2AP.
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The effect of intrapartum chemoprophylaxis on the vertical transmission of group B streptococci
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1983.tb09280.x
Issue
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BJOG: An International Journal of Obstetrics & Gynaecology
Volume 90, Issue 7, pages 633–635, July 1983
Additional Information
How to Cite
EASMON, C. S. F., HASTINGS, M. J. G., DEELEY, J., BLOXHAM, B., RIVERS, R. P. A. and MARWOOD, R. (1983), The effect of intrapartum chemoprophylaxis on the vertical transmission of group B streptococci. BJOG: An International Journal of Obstetrics & Gynaecology, 90: 633–635. doi: 10.1111/j.1471-0528.1983.tb09280.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Received 29th November 1982 Accepted 20th March, 1983
- Abstract
- References
- Cited By
Summary. Intrapartum chemoprophylaxis with benzylpenicillin or erythromycin significantly reduced the rate of transmission of group B streptococci (GBS) from mothers colonized during pregnancy to their babies from 45% to 3% (P<0.001). None of the babies born to women who were given prophylaxis was colonized with GBS in the first 24 h of life. Six weeks after leaving hospital, however, 23% of the babies in the antibiotic group had become colonized with GBS compared with 44% in the control group. GBS strains resistant and tolerant to both benzylpenicillin and erythromycin were found in this study. Intrapartum chemoprophylaxis breaks the cycle of GBS transmission at birth and may be useful in preventing early onset GBS disease, but is unlikely to affect late onset infections.