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Ten-year survival in 290 patients with endometrial cancer: prognostic factors and therapeutic approach
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1983.tb09285.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 90, Issue 7, pages 654–661, July 1983
Additional Information
How to Cite
LA VECCHIA, C., FRANCESCHI, S., PARAZZINI, F., COLOMBO, E., COLOMBO, F., LIBERATI, A. and MANGIONI, C. (1983), Ten-year survival in 290 patients with endometrial cancer: prognostic factors and therapeutic approach. BJOG: An International Journal of Obstetrics & Gynaecology, 90: 654–661. doi: 10.1111/j.1471-0528.1983.tb09285.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Received 4 September 1982 Accepted 10 January 1983
- Abstract
- References
- Cited By
Summary. Between 1970 and 1976, 290 patients with endometrial cancer were treated at the 1st Obstetrics and Gynecology Clinic of the University of Milan. The median age was 62 years. Surgery was completed in 262 (90.3%) patients. Abdominal hysterectomy was used in 158 (70.9%) stage I and 40 (71.4%) stage II/III patients; vaginal hysterectomy in 55 (24.7%) stage I and nine (16.1%) stage II/III patients. Resection of the upper vagina was performed in 168 patients. Postoperative external beam radiotherapy was used in stage II/III patients and in 44 (19.7%) stage I high-risk patients. Ten-year survival, determined by the life-table method, was 84.8% in stage I (223 patients), 53.4% in stage II (37 patients), 64.4% in stage III (19 patients), and 9.1% in stage IV (11 patients). Factors associated with poorer prognosis were: late age at diagnosis (P<0.001); deep myometrial invasion (P<0.001); poorly differentiated histological grade (P=0.11); lack of resection of the upper vagina (P= 0.13). The role and importance of surgery is discussed, with special emphasis on the selective use of the vaginal route in aged, obese and medically high-risk patients.