The value of immunohistochemical markers in the diagnosis of cervical neoplasia

  1. R. E. FRAY Senior Registrar 1,
  2. O. A. N. HUSAIN Consultant 2,
  3. A. C. W. TO Senior Scientist 2,
  4. K. C. WATTS Senior Scientist 2,
  5. S. LADER Trials Organizer 3,
  6. G. T. ROGERS Principal Biochemist 4,
  7. J. TAYLOR-PAPADIMITRIOU Senior Scientist 5,
  8. N. F. MORRIS Professor 1

Article first published online: 23 AUG 2005

DOI: 10.1111/j.1471-0528.1984.tb03684.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 91, Issue 10, pages 1037–1041, October 1984

Additional Information

How to Cite

FRAY, R. E., HUSAIN, O. A. N., TO, A. C. W., WATTS, K. C., LADER, S., ROGERS, G. T., TAYLOR-PAPADIMITRIOU, J. and MORRIS, N. F. (1984), The value of immunohistochemical markers in the diagnosis of cervical neoplasia. BJOG: An International Journal of Obstetrics & Gynaecology, 91: 1037–1041. doi: 10.1111/j.1471-0528.1984.tb03684.x

Author Information

  1. 1

    Department of Obstetrics and Gynaecology, West London Hospital, London W6

  2. 2

    Department of Cytology, Charing Cross and St Stephen's Hospital, Chelsea

  3. 3

    Wellcome Diagnostics, Beckenham, Kent

  4. 4

    Department of Medical Oncology, Charing Cross Hospital, London W6

  5. 5

    Imperial Cancer Research Fund, London

Publication History

  1. Issue published online: 23 AUG 2005
  2. Article first published online: 23 AUG 2005
  3. Received 4 November 1983 Accepted 5 February 1984

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Summary. This study was designed to determine whether immunohistochemical stains for tumour-associated markers may be useful in the detection and differential diagnosis of premalignant and malignant lesions of the cervix. The expression of four markers detected by monoclonal antibodies, human milk fat globule 1 and 2 (HMFG-1 and 2), Cal and anti-carcinoembryonic antigen (anti-CEA) on conventional histological sections of various cervical lesions has been investigated. None of these markers was specific for neoplastic lesions of the cervix and all four markers were expressed by metaplastic as well as neoplastic cells, and it was concluded that their application in the histopathological examination of the cervix is limited.

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