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Ratio of amniotic fluid acetylcholinesterase to pseudocholinesterase as an antenatal diagnostic test for exomphalos and gastroschisis
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1984.tb03701.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 91, Issue 9, pages 882–884, September 1984
Additional Information
How to Cite
WALD, N. J., BARLOW, R. D., CUCKLE, H. S., TURNBULL, A. C., GOLDFINE, C. and HADDOW, J. E. (1984), Ratio of amniotic fluid acetylcholinesterase to pseudocholinesterase as an antenatal diagnostic test for exomphalos and gastroschisis. BJOG: An International Journal of Obstetrics & Gynaecology, 91: 882–884. doi: 10.1111/j.1471-0528.1984.tb03701.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Received 5 October 1983 Accepted 5 December 1983
- Abstract
- References
- Cited By
Summary. Amniotic fluid samples from eight pregnancies associated with exomphalos or gastroschisis and 24 with open spina bifida were used to confirm the hypothesis that when the α-fetoprotein and gel acetylcholinesterase tests are positive in an amniotic fluid not visibly contaminated with blood, the two defects can be distinguished by scanning densitometry of the electrophoretic gel. The ratio of the density for the acetylcholinesterase band in the gel to that of the pseudocholinesterase band was ≤0.10 for the open abdominal wall defects and 0.27 or more for open spina bifida. Based on this and a previously reported series, a cut-off level of about 0.15 is suggested.