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Does smoking influence serum α-fetoprotein levels in mid-trimester pregnancies?
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1984.tb04735.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 91, Issue 12, pages 1188–1191, December 1984
Additional Information
How to Cite
HADDOW, J. E., PALOMAKI, G., KLOZA, E. M., KNIGHT, G. J. and WYLIE, P. (1984), Does smoking influence serum α-fetoprotein levels in mid-trimester pregnancies?. BJOG: An International Journal of Obstetrics & Gynaecology, 91: 1188–1191. doi: 10.1111/j.1471-0528.1984.tb04735.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Received 20 February 1984; Accepted 7 March 1984
- Abstract
- References
- Cited By
Summary. The effect of cigarette smoking during pregnancy on serum α-fetoprotein (AFP) levels was studied in 1925 consecutive women at 16–18 weeks gestation who subsequently had liveborn singleton infants. Cotinine and AFP were measured in sera in all the women and answers to a smoking questionnaire were analysed in 894. Cotinine, a metabolic derivative of nicotine, serves as an objective measure of the average daily absorption of smoking products because of its relatively long half-life. Infants born to women who smoked were, on average, 198 g lighter than those born to non-smokers, even though maternal weights were comparable. Whether analysed by self-reporting or by serum cotinine, cigarette smoking had no measurable effect on serum AFP levels.