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The presence of RNA complementary to HSV-2 (herpes simplex virus) DNA in cervical intraepithelial neoplasia after laser therapy
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1984.tb04765.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 91, Issue 3, pages 265–269, March 1984
Additional Information
How to Cite
EGLIN, R. P., KITCHENER, H. C., MacLEAN, A. B., DENHOLM, R. B., CORDINER, J. W. and SHARP, F. (1984), The presence of RNA complementary to HSV-2 (herpes simplex virus) DNA in cervical intraepithelial neoplasia after laser therapy. BJOG: An International Journal of Obstetrics & Gynaecology, 91: 265–269. doi: 10.1111/j.1471-0528.1984.tb04765.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Received 28 March 1983 Accepted 5 September 1983
- Abstract
- References
- Cited By
summary
In-situ hybridization of radiolabelled DNA probes to tissue sections detected RNA complementary to HSV-2 (herpes simplex virus) DNA in 65% (22 of 34) biopsies from cervical intraepithelial neoplasia (CIN) and in none of internally paired benign epithelia from individuals before treatment by laser vaporization cone. Laser therapy did not produce an increase in clinical or subclinical HSV infections of the cervix. Of 18 patients with RNA complementary to HSV-2 DNA in CIN biopsies before treatment, in whom treatment was successful, virus transcripts were detected at follow-up in only two of them.