Immunoreactive trypsin and the prenatal diagnosis of cystic fibrosis

  1. DAVID J. H. BROCK Director1,*,
  2. CAROLINE HAYWARD Research Assistant, Human Genetics Unit1,
  3. CHRISTINE GOSDEN Scientist1,
  4. CHARLES RODECK Director2

Article first published online: 23 AUG 2005

DOI: 10.1111/j.1471-0528.1984.tb04782.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 91, Issue 5, pages 449–452, May 1984

Additional Information

How to Cite

BROCK, D. J. H., HAYWARD, C., GOSDEN, C. and RODECK, C. (1984), Immunoreactive trypsin and the prenatal diagnosis of cystic fibrosis. BJOG: An International Journal of Obstetrics & Gynaecology, 91: 449–452. doi: 10.1111/j.1471-0528.1984.tb04782.x

Author Information

  1. 1

    MRC Clinical Population Cytogenetics Unit, Western General Hospital, Edinburgh

  2. 2

    Harris-Birthright Research Centre for Fetal Medicine, Kings College Hospital Medical School, London

* David J. H. Brock, Director, Human Genetics Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU.

Publication History

  1. Issue published online: 23 AUG 2005
  2. Article first published online: 23 AUG 2005
  3. Received 2 August 1983 Accepted 10 November 1983

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Immunoreactive trypsin (IRT) was measured by radio-immunoassay in a series of amniotic fluids obtained at between 15 and 19 weeks from pregnancies with a 1-in-4 risk of fetal cystic fibrosis. IRT concentrations were significantly depressed in nine affected pregnancies, but the degree of overlap with the normal range was too great for this to be useful in early prenatal diagnosis. Furthermore, in one fetus, presumed to have cystic fibrosis, the fetal plasma IRT concentration was within the normal range.

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