The transfer of cephradine across the placenta

  1. I. R. LANGE Head, High Risk Obstetrics1,*,
  2. C. RODECK Senior Lecturer2,
  3. R. COSGROVE3

Article first published online: 23 AUG 2005

DOI: 10.1111/j.1471-0528.1984.tb04801.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 91, Issue 6, pages 551–554, June 1984

Additional Information

How to Cite

LANGE, I. R., RODECK, C. and COSGROVE, R. (1984), The transfer of cephradine across the placenta. BJOG: An International Journal of Obstetrics & Gynaecology, 91: 551–554. doi: 10.1111/j.1471-0528.1984.tb04801.x

Author Information

  1. 1

    Department of Obstetrics and Gynaecology, St Boniface General Hospital, Winnipeg, Canada

  2. 2

    Department of Obstetrics and Gynaecology, King's College Medical School, London

  3. 3

    International Development Laboratory, Moreton, Merseyside

* I. R. Lange, Head, High Risk Obstetrics, Department of Obstetrics and Gynaecology, St Boniface General Hospital, 409 Tache Avenue, Manitoba R2H 2A6, Canada.

Publication History

  1. Issue published online: 23 AUG 2005
  2. Article first published online: 23 AUG 2005
  3. Received 3 March 1983 Accepted 6 January 1984

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Summary

The transfer of maternally administered cephradine (1 g given intravenously) to the fetal circulation and amniotic fluid was investigated in 2 pregnant patients undergoing fetoscopy. Cephradine was detected in fetal serum between 23 and 72 minutes after injection and was present in therapeutic concentrations. Fetal serum levels appeared to peak at approximately 40–50 min. Amniotic fluid levels were rising during the sampling period of 97 min. Cephradine is transferred across the placenta and appears to be a suitable antibiotic for use in selected obstetric patients when penetration of the fetal compartment is desirable.

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