Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania 17033, USA.
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A functional study of platelets in menstrual fluid
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1984.tb04828.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 91, Issue 7, pages 667–672, July 1984
Additional Information
How to Cite
REES, M. C. P., DEMERS, L. M., ANDERSON, A. B. M. and TURNBULL, A. C. (1984), A functional study of platelets in menstrual fluid. BJOG: An International Journal of Obstetrics & Gynaecology, 91: 667–672. doi: 10.1111/j.1471-0528.1984.tb04828.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Received 4 May 1983 Accepted 22 October 1983
- Abstract
- References
- Cited By
Summary.
Platelets were isolated from menstrual and peripheral venous blood samples taken from nine women during the first 2 days of menstruation. The washed platelets were tested for their ability to aggregate in response to arachidonic acid, ADP, and collagen, and to metabolize arachidonic acid. Menstrual platelets differed from venous platelets in (1) failing to aggregate when challenged with aggregatory stimuli and (2) producing no appreciable cyclo-oxygenase products from arachidonic acid as reflected in thromboxane B2 release. However, incubation of peripheral venous platelets with menstrual serum obtained from the same patients induced aggregation. The responses of menstrual and peripheral venous platelets were the same irrespective of the patients’ total menstrual blood loss. Uterine venous platelets collected during menstruation from two patients at hysterectomy aggregated normally and produced thromboxane B2.