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Measurement of placental alkaline phosphatase in maternal plasma as an indicator of subsequent low birthweight outcome
Article first published online: 19 AUG 2005
DOI: 10.1111/j.1471-0528.1988.tb06484.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 95, Issue 1, pages 79–83, January 1988
Additional Information
How to Cite
BROCK, D. J.H. and BARRON, L. (1988), Measurement of placental alkaline phosphatase in maternal plasma as an indicator of subsequent low birthweight outcome. BJOG: An International Journal of Obstetrics & Gynaecology, 95: 79–83. doi: 10.1111/j.1471-0528.1988.tb06484.x
Publication History
- Issue published online: 19 AUG 2005
- Article first published online: 19 AUG 2005
- Received 15 December 1986, Accepted 4 May 1987
- Abstract
- References
- Cited By
Summary. Placental alkaline phosphatase (P-ALP) was measured by a specific monoclonal antibody-based immunoassay in plasma samples of 117 women who subsequently were delivered of an infant of birthweight less than 2·5 kg. P-ALP values > twice the normal median were found in 32% of maternal plasma samples from low birthweight cases in one scries and in 35% in another series, while in normal outcome controls the corresponding value was 8%. The differences were highly significant. The proportion of low birthweight cases with elevated maternal P-ALP values appears to be very similar between 15 and 34 weeks gestation. At 16–18 weeks gestation there is a significant positive correlation (r = 0·40) between P-ALP and maternal plasma alpha-fetoprotein (AFP) values in low birthweight cases. The use of P-ALP assay in combination with AFP assay appears to improve the detection of pregnancies with subsequent low birthweight outcome.