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Plasma corticotrophin-releasing factor (CRF) in normal pregnancy

  1. C. D. A. WOLFE Research Registrar1,*,
  2. S. P. PATEL Lecturer in Medical Statistics2,
  3. E. A. CAMPBELL Research Fellow1,†,
  4. E. A. LINTON Research Fellow3,
  5. J. ANDERSON Medical Student1,
  6. P. J. LOWRY Professor3,
  7. M. T. JONES Professor1

Article first published online: 19 AUG 2005

DOI: 10.1111/j.1471-0528.1988.tb06503.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 95, Issue 10, pages 997–1002, October 1988

Additional Information

How to Cite

WOLFE, C. D. A., PATEL, S. P., CAMPBELL, E. A., LINTON, E. A., ANDERSON, J., LOWRY, P. J. and JONES, M. T. (1988), Plasma corticotrophin-releasing factor (CRF) in normal pregnancy. BJOG: An International Journal of Obstetrics & Gynaecology, 95: 997–1002. doi: 10.1111/j.1471-0528.1988.tb06503.x

Author Information

  1. 1

    Division of Gynaecology, UMDS St Thomas's Campus, London SE1 7EH

  2. 2

    Department of Community Medicine, UMDS St Thomas's Campus, London SE1 7EH

  3. 3

    Department of Physiology and Biochemistry, Reading University

  1. †

    Sandoz Institute for Medical Research, 5 Gower Place, London WC1E 6BN

* C. D. A. Wolfe

Publication History

  1. Issue published online: 19 AUG 2005
  2. Article first published online: 19 AUG 2005
  3. SReceived 27 August 1987, Accepted 3 February 1988

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Summary. Corticotrophin-releasing factor (CRF) was measured directly in maternal plasma using an immunoradiometric assay (IRMA). In the first and second trimester CRF levels were within the non-pregnant range (mean 15 pg/ml). A total of 72 women was followed sequentially from 28 weeks until delivery and CRF levels rose from a median of 20 pg/ml at 28 weeks to 1320 pg/ml at 40 weeks and 1732 pg/ml during labour. There was a strong correlation (rs= 0·81, P<0·001) between gestational age and CRF levels. The rate of rise of CRF (pg/ml) per week was associated with weight gain (rs= 0·36, P<0·05) but with no other obstetric variable. There was an association between umbilical cord and maternal plasma CRF levels (rs= 0·54, P<0·01).

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