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Plasma corticotrophin-releasing factor (CRF) in abnormal pregnancy

  1. C. D. A. WOLFE Research Registrar1,*,
  2. E. A. CAMPBELL Research Fellow1,†,
  3. J. ANDERSON Medical Student1,
  4. M. T. JONES Professor1,
  5. S. P. PATEL Lecturer in Medical Statistics2,
  6. A. DORNHORST Senior Registrar3,
  7. E. A. LINTON Research Fellow4,
  8. P. J. LOWRY Professor4

Article first published online: 19 AUG 2005

DOI: 10.1111/j.1471-0528.1988.tb06504.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 95, Issue 10, pages 1003–1006, October 1988

Additional Information

How to Cite

WOLFE, C. D. A., CAMPBELL, E. A., ANDERSON, J., JONES, M. T., PATEL, S. P., DORNHORST, A., LINTON, E. A. and LOWRY, P. J. (1988), Plasma corticotrophin-releasing factor (CRF) in abnormal pregnancy. BJOG: An International Journal of Obstetrics & Gynaecology, 95: 1003–1006. doi: 10.1111/j.1471-0528.1988.tb06504.x

Author Information

  1. 1

    Division of Gynaecology, UMDS St Thomas's Campus, London SE1 TEH

  2. 2

    Department of Community Medicine, UMDS St Thomas's Campus, London SE1 TEH

  3. 3

    Department of Medicine, St Mary's Hospital Medical School, London W2 1NY

  4. 4

    Department of Physiology and Biochemistry, Reading University

  1. †

    Sandoz Institute for Medical Research, 5 Gower Place, London WC1E 6BN

* C. D. A. Wolfe

Publication History

  1. Issue published online: 19 AUG 2005
  2. Article first published online: 19 AUG 2005
  3. Received 27 August 1987, Accepted 3 February 1988

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Summary. Maternal plasma levels of cortiocotrophin-releasing factor (CRF) have been measured in abnormal pregnancy states to assess their potential as biochemical markers for at-risk pregnancies. CRF levels were not significantly altered in patients with hydatidiform mole, polyhydramnios or diabetes. CRF levels were elevated in pregnancies complicated by accidental antepartum haemorrhage at 28 weeks (P<0·03) but not for the rest of the third trimester. In twin pregnancies CRF levels were significantly raised throughout the third trimester (28–32 weeks, P<0·01; 34–36 weeks, P<0·001). In patients with pregnancy-induced hypertension (28 weeks, P<0·001; 32–36 weeks, P<0·001; and 38–40 weeks, P<0·01), preterm labour and premature rupture of the membranes (28 weeks, P<0·004; 30–32 weeks, P<0·002; and 34–36 weeks, P<0·001), CRF levels were significantly raised and in some patients levels were elevated 11 weeks before the onset of signs or symptoms. These observations raise the possibility that maternal CRF measurement may be of use as a predictive indicator of certain at-risk pregnancies.

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