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Surfactant stimulates prostaglandin E production in human amnion
Article first published online: 19 AUG 2005
DOI: 10.1111/j.1471-0528.1988.tb06506.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 95, Issue 10, pages 1013–1017, October 1988
Additional Information
How to Cite
BERNAL, A. L., NEWMAN, G. E., PHIZACKERLEY, P. J. R. and TURNBULL, A. C. (1988), Surfactant stimulates prostaglandin E production in human amnion. BJOG: An International Journal of Obstetrics & Gynaecology, 95: 1013–1017. doi: 10.1111/j.1471-0528.1988.tb06506.x
Publication History
- Issue published online: 19 AUG 2005
- Article first published online: 19 AUG 2005
- Received 4 November 1987, Accepted 21 January 1988
- Abstract
- References
- Cited By
Summary. Discs of human amnion prepared from nine women delivered by elective caesarean section at term were incubated with and without purified human amniotic fluid surfactant (9 μg lipid P/ml), and the output of prostaglandin E (PGE) was estimated by radioimmunoassay. Surfactant stimulated the release of PGE from 3·8 (SD 2·9) to 5·4 (SD 2·5) pmol/mg dry weight/3 h (P<0·01). Arachidonic acid accounted for 2% of the fatty acids of surfactant lecithin. These results show that surfactant has a stimulatory effect on amniotic PGE production and that it is an important source of arachidonic acid in amniotic fluid.