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Genetic control of susceptibility to eclampsia and miscarriage

  1. DESMOND W. COOPER Professor of Biology1,*,
  2. JOSEPH A. HILL Obstetrician2,
  3. LEON C. CHESLEY Professor Emeritus3,
  4. C. IVERSON BRYANS Professor Emeritus4

Article first published online: 19 AUG 2005

DOI: 10.1111/j.1471-0528.1988.tb06524.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 95, Issue 7, pages 644–653, July 1988

Additional Information

How to Cite

COOPER, D. W., HILL, J. A., CHESLEY, L. C. and BRYANS, C. I. (1988), Genetic control of susceptibility to eclampsia and miscarriage. BJOG: An International Journal of Obstetrics & Gynaecology, 95: 644–653. doi: 10.1111/j.1471-0528.1988.tb06524.x

Author Information

  1. 1

    School of Biological Sciences, Macquarie University, New South Wales, 2109, Australia

  2. 2

    Department of Obstetrics and Gynecology, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA

  3. 3

    Department of Obstetrics and Gynecology, State University of New York, Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA

  4. 4

    Department of Obstetrics and Gynecology, School of Medicine, Medical College of Georgia, Augusta, GA 30912, USA

* D. W. Cooper

Publication History

  1. Issue published online: 19 AUG 2005
  2. Article first published online: 19 AUG 2005
  3. Received 14 April 1987, Accepted 4 October 1987

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Summary. An analysis has been made of 48 pedigrees selected (ascertained) through an affected mother in the first generation. These pedigrees mainly involve cases of eclampsia which occurred before its recent decline in incidence. The data confirm the genetic determination of susceptibility indicated by published data on eclampsia/preeclampsia. There is a suggestion that the fetal genotype can contribute to susceptibility to eclampsia in its mother, in contrast to previous findings that susceptibility to pre-eclampsia is controlled solely by the maternal genotype. An association between eclampsia and miscarriage is shown in the data. We argue that this suggests that the primary mode of action of the gene(s) involved is to affect the interaction between uterine and placental tissue.

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