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Trophoblast membrane infusion for unexplained recurrent miscarriage

  1. P. M. JOHNSON Professor of Immunology1,*,
  2. K. V. CHIA Clinical Research Fellow1,
  3. C. A. HART Professor of Medical Microbiology2,
  4. H. B. GRIFFITH Consultant Obstetrician and Gynaecologist3,
  5. W. J. A. FRANCIS Consultant Obstetrician and Gynaecologist4

Article first published online: 19 AUG 2005

DOI: 10.1111/j.1471-0528.1988.tb06603.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 95, Issue 4, pages 342–347, April 1988

Additional Information

How to Cite

JOHNSON, P. M., CHIA, K. V., HART, C. A., GRIFFITH, H. B. and FRANCIS, W. J. A. (1988), Trophoblast membrane infusion for unexplained recurrent miscarriage. BJOG: An International Journal of Obstetrics & Gynaecology, 95: 342–347. doi: 10.1111/j.1471-0528.1988.tb06603.x

Author Information

  1. 1

    University of Liverpool, PO Box 147, Liverpool L69 3BX, UK Department of Immunology

  2. 2

    Department of Medical Microbiology

  3. 3

    Warrington General Hospital, Warrington WA5 1QG

  4. 4

    Liverpool Women's Hospital, Catherine Street, Liverpool L8 7NJ

* Professor P. M. Johnson

Publication History

  1. Issue published online: 19 AUG 2005
  2. Article first published online: 19 AUG 2005
  3. Received 22 June 1987 Accepted 18 August 1987

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Summary. A novel protocol is described which has been developed for immunotherapy in unexplained recurrent miscarriage. This is based on a single intravenous infusion with isolated placental trophoblast plasma membrane vesicle preparations. Clinical experience gained with this approach is described. A total of 16/21 (76%) patients who subsequently had pregnancies have now achieved a live birth or are currently pregnant at greater than 28 weeks gestation.

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