Department of Obstetrics and Gynaecology, Mater Misericordiae Mothers Hospital, South Brisbane, Queensland, 4101 Australia
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Beta-mimetics in preterm labour: an overview of the randomized controlled trials
Article first published online: 19 AUG 2005
DOI: 10.1111/j.1471-0528.1988.tb06860.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 95, Issue 3, pages 211–222, March 1988
Additional Information
How to Cite
KING, J. F., GRANT, A., KEIRSE, M. J. N. C. and CHALMERS, I. (1988), Beta-mimetics in preterm labour: an overview of the randomized controlled trials. BJOG: An International Journal of Obstetrics & Gynaecology, 95: 211–222. doi: 10.1111/j.1471-0528.1988.tb06860.x
Publication History
- Issue published online: 19 AUG 2005
- Article first published online: 19 AUG 2005
- Received 17 June 1987 Accepted 18 August 1987
- Abstract
- References
- Cited By
Summary. Controversy continues about the use of beta-mimetic drugs in preterm labour. One reason for this is that the adequately controlled trials of these drugs have all been small and have thus provided very imprecise estimates of their effects. We have therefore conducted a‘meta-analysis’ using data relating to 890 women who participated in the 16 methodologically acceptable controlled trials of these agents in the treatment of preterm labour. This analysis demonstrates an unequivocal effect of beta-mimetic tocolytic administration in delaying delivery, and this is reflected in a reduction in the frequency of preterm birth and low birthweight. However, no beneficial effect of this treatment on perinatal mortality or severe neonatal respiratory disorders could be detected.