Nausea and vomiting of early pregnancy and pregnancy outcome. An epidemiological study

Authors

  • M. MARGARET WEIGEL,

    Corresponding author
    1. Division of Foods and Nutrition School of Human Resources and Family Studies, College of Agriculture, and Department of Obstetrics and Gynecology, College of Medicine, University of Illinois, Urbana, Illinois, USA
    Search for more papers by this author
  • RONALD M. WEIGEL

    1. Division of Epidemiology and Preventive Medicine, Department of Pathohiology, College of Veterinary Medicine, and Department of Health and Safety Studies, College of Applied Life Studies, University of Illinois, Urbana. Illinois, USA
    Search for more papers by this author

M. Margaret Weigel. PhD. Division of Foods and Nutrition, School of Human Resources and Family Studies, University of Illinois, 443 Bevier Hall, 905 South Goodwin Avenue, Urbnna, Illinois 61801, USA

Summary

The association of nausea and vomiting in pregnancy with the outcome of pregnancy was investigated in a historical cohort of 903 women in Los Angeles, California, USA. Multivariahle statistical methods were employed to control for the potential confounding effects of age, ethnicity, occupation, and anti-emetic use on pregnancy outcome. The analyses indicated that vomiting was associated with decreased risk of miscarriage (adjusted odds ratio 0·18, 95% CI 0·06 to 0·53); women with nausea but no vomiting had a miscarriage risk equal to that in the sample overall. Among the subsample of women with signs of threatened miscarriage, those who had experienced vomiting had a decreased risk of miscarriage (10·3%vs 31·7% in the subsample). No statistically significant association was observed between nausea and vomiting of pregnancy and other pregnancy outcomes (perinatal mortality, fetal anomalies, neonatal anthropometric measures).

Ancillary