Immunohistochemical determination of tumour growth fraction in human ovarian carcinoma

Authors

  • W. S. FELIX WONG,

    Corresponding author
    1. Ludwig Institute for Cancer Research (Sydney Branch), Department of Cancer Medicine, Blackburn Building, University of Sydney, Sydney, NSW 2006, Australia
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  • MARTIN H. N. TATTERSALL

    1. Ludwig Institute for Cancer Research (Sydney Branch), Department of Cancer Medicine, Blackburn Building, University of Sydney, Sydney, NSW 2006, Australia
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Dr W. S. Felix Wong, Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital. Shatin, Hong Kong

Abstract

Summary. The proportion of proliferating tumour cells in a tumour (‘growth fraction’) was estimated in 30 patients with primary ovarian carcinoma, using monoclonal antibody Ki-67 which reacts with a nuclear antigen present only in proliferating cells. A positive correlation between the ‘growth fraction’ and both the clinical stage and histological grade of the tumours was observed. A high ‘growth fraction’ was observed in advanced, metastatic and poorly differentiated tumours and a low ‘growth fraction’ with early stage, well-differentiated tumours. This information which has not been available previously to clinicians may be of practical value for determining the prognosis, and influencing treatment recommendation.

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