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Oligohydramnios associated with prostaglandin synthetase inhibitors in preterm labour
Article first published online: 19 AUG 2005
DOI: 10.1111/j.1471-0528.1990.tb01807.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 97, Issue 4, pages 312–316, April 1990
Additional Information
How to Cite
HENDRICKS, S. K., SMITH, J. R., MOORE, D. E. and BROWN, Z. A. (1990), Oligohydramnios associated with prostaglandin synthetase inhibitors in preterm labour. BJOG: An International Journal of Obstetrics & Gynaecology, 97: 312–316. doi: 10.1111/j.1471-0528.1990.tb01807.x
Publication History
- Issue published online: 19 AUG 2005
- Article first published online: 19 AUG 2005
- Received 23 June 1989; Accepted 12 September 1989
- Abstract
- References
- Cited By
Summary. The use of prostaglandin synthetase inhibitors (indomethacin and ibuprofen) for >72 h in women with preterm labour (n=67) was significantly (P<0.001) associated with ultrasoundrecorded oligohydramnios compared with the use of ritodrine or magnesium sulphate (control group, n=67). Oligohydramnios developed in 26 of 37 women (70%) treated with indomethacin and 8 of 30 women treated with ibuprofen (27%) (P<0.01). Oligohydramnios developed in only two control subjects and one of these pregnancies was associated with intrauterine growth retardation. All 34 cases of oligohydramnios in the treatment group resolved after stopping medication, whereas the two in the control group did not resolve. No instances of renal failure, premature closure of the ductus arteriosus, pulmonary hypertension, or bleeding disorders were noted in any of the treated or control infants.