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Rapid pulses of luteinizing hormone during the ovarian cycle

  1. A. P. MURDOCH Senior Registrar1,*,
  2. P. J. DIGGLE Professor of Staristics3,
  3. M. C. WHITE First Assistant2,
  4. P. KENDALL-TAYLOR Professor of Endocrinology2,
  5. W. DUNLOP Professor1

Article first published online: 19 AUG 2005

DOI: 10.1111/j.1471-0528.1990.tb01810.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 97, Issue 4, pages 329–333, April 1990

Additional Information

How to Cite

MURDOCH, A. P., DIGGLE, P. J., WHITE, M. C., KENDALL-TAYLOR, P. and DUNLOP, W. (1990), Rapid pulses of luteinizing hormone during the ovarian cycle. BJOG: An International Journal of Obstetrics & Gynaecology, 97: 329–333. doi: 10.1111/j.1471-0528.1990.tb01810.x

Author Information

  1. 1

    Departments of Obstetrics and Gynaecology, University of Newcastle upon Tyne

  2. 2

    Department of Medicine, University of Newcastle upon Tyne

  3. 3

    Department of Mathematics, University of Lancaster

* Dr A. P. Murdoch, Princess Mary Maternity Hospital, Great North Road, Newcastle upon Tyne

Publication History

  1. Issue published online: 19 AUG 2005
  2. Article first published online: 19 AUG 2005
  3. Received 14 July 1989; Accepted 30 October 1989

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Summary. Luteinizing hormone has been shown to be secreted in a complex pattern of low-amplitude, high-frequency pulses superimposed on high-amplitude, low-frequency pulses. To test the hypothesis that the rapid, small pulses vary during the ovarian cycle, 16 normal women were studied on two occasions each, in the early and late follicular phases of one cycle or the luteal and following early follicular phase. Blood samples were taken every 1 min for 1 h. Statistical methods of time series analysis were applied to the data. There were significant amplitude differences between subjects at all stages of the cycle. We found no evidence to support the hypothesis that the frequency of the small rapid pulses varied during folliculogenesis. The results for the luteal phase, while less uniform, showed no consistent change. It is suggested that the rapid pulses may be related to function of the hypothalamic-pituitary axis rather than direct ovarian control.

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