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Effects of isradipine, a new calcium antagonist, on maternal cardiovascular system and uterine activity in labour
Article first published online: 19 AUG 2005
DOI: 10.1111/j.1471-0528.1990.tb02452.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 97, Issue 10, pages 945–949, October 1990
Additional Information
How to Cite
WIDE-SWENSSON, D., TNGEMARSSON, T., ARULKUMARAN, S. and ANDERSSON, K.-E. (1990), Effects of isradipine, a new calcium antagonist, on maternal cardiovascular system and uterine activity in labour. BJOG: An International Journal of Obstetrics & Gynaecology, 97: 945–949. doi: 10.1111/j.1471-0528.1990.tb02452.x
Publication History
- Issue published online: 19 AUG 2005
- Article first published online: 19 AUG 2005
- Received 11 August 1989 Accepted 10 February 1990
- Abstract
- References
- Cited By
Summary. The effects of isradipine (a new calcium antagonist of the dihydropyridine type) on maternal blood pressure and heart rate, fetal heart rate, and uterine activity in labour were measured. Uterine activity was recorded by an intrauterine microtip transducer catheter connected to a fetal monitor. Isradipine was given as a slow injection in doses of 0.5 mg (10 women), 1 mg (11 women), and 1.5 mg (6 women). A reduction of systolic (6–16%) and diastolic (19-22%) blood pressure was seen, and concomitantly there was an increase in maternal (29–34%) and fetal (3–10%) heart rates. Reduction in uterine activity was not dose-related (maximum reduction 17%). Side effects (headache, palpitations) were minor and well tolerated. One woman in the highdose group had a shortlasting episode of hypotension. The results suggest that isradipine given as a bolus dose decreases blood pressure in pregnant women with little effects on uterine activity and fetal heart rate.