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The treatment of detrusor instability in postmenopausal women with oxybutynin chloride: a double blind placebo controlled study
Article first published online: 19 AUG 2005
DOI: 10.1111/j.1471-0528.1990.tb02523.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 97, Issue 6, pages 521–526, June 1990
Additional Information
How to Cite
TAPP, A. J. S., CARDOZO, L. D., VERSI, E. and COOPER, D. (1990), The treatment of detrusor instability in postmenopausal women with oxybutynin chloride: a double blind placebo controlled study. BJOG: An International Journal of Obstetrics & Gynaecology, 97: 521–526. doi: 10.1111/j.1471-0528.1990.tb02523.x
Publication History
- Issue published online: 19 AUG 2005
- Article first published online: 19 AUG 2005
- Received 21 July 1987; Resubmitted 31 Angust 1989; Accepted 23 November 1989
- Abstract
- References
- Cited By
Summary. Idiopathic detrusor instability is a common cause of incontinence in the elderly for which anticholinergic agents arc regularly prescribed. Oxybutynin chloride combines anticholinergic action with direct muscle relaxant properties. We performed a double blind placebo controlled fixed dose cross over study of oxybutynin chloride in postmenopausal women suffering from detrusor instability. We found oxybutynin chloride significantly more effective than placebo at reducing the symptoms of urgency and urge incontinence and more effective at reducing the height of the highest unstable detrusor contraction. This was at the expense of an increased residual urine and considerable side effects.