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Luteal phase deficiency: ultrasonic and biochemical insights into pathogenesis
Article first published online: 19 AUG 2005
DOI: 10.1111/j.1471-0528.1990.tb02542.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 97, Issue 7, pages 569–575, July 1990
Additional Information
How to Cite
HAMILTON, M. P. R., FLEMING, R., COUTTS, J. R. T., MACNAUGHTON, M. C. and WHITFIELD, C. R. (1990), Luteal phase deficiency: ultrasonic and biochemical insights into pathogenesis. BJOG: An International Journal of Obstetrics & Gynaecology, 97: 569–575. doi: 10.1111/j.1471-0528.1990.tb02542.x
Publication History
- Issue published online: 19 AUG 2005
- Article first published online: 19 AUG 2005
- Received 24 October 1989; Accepted 24 January 1990
- Abstract
- References
- Cited By
Summary. Serial ovarian ultrasound and daily assessments of plasma concentrations of pituitary and ovarian hormones were used to investigate ovarian function in 175 women with unexplained infertility. Their endocrine and ultrasound profiles were compared with similarly derived data from 43 normal volunteers. Fifty-one (29·1%) of the study group showed subnormal luteal phase rises in progesterone concentrations, described as poor progesterone surge (PPS) cycles. Within this group, 23 women (45·1%) demonstrated luteal cyst formation, a pattern not seen in any of the control cycles. High concentrations of follicle stimulating hormone (FSH) and reduced concentrations of oestradiol (E2) were observed in the follicular phases of the PPS cycles suggesting that the phenomenon is a product of abnormal follicular metabolism. An association of PPS with infertility exists, perhaps related to a combination of disturbances in the follicular micro-environment compromising oocyte quality, a failure of oocyte release, and impaired endometrial receptivity.