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No effect of intralesional injection of interferon on moderate cervical intraepithelial neoplasia
Article first published online: 19 AUG 2005
DOI: 10.1111/j.1471-0528.1990.tb02552.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 97, Issue 7, pages 626–630, July 1990
Additional Information
How to Cite
FROST, L., SKAJAA, K., HVTDMAN, L. E., FAY, S. J. and LARSEN, P. M. (1990), No effect of intralesional injection of interferon on moderate cervical intraepithelial neoplasia. BJOG: An International Journal of Obstetrics & Gynaecology, 97: 626–630. doi: 10.1111/j.1471-0528.1990.tb02552.x
Publication History
- Issue published online: 19 AUG 2005
- Article first published online: 19 AUG 2005
- Abstract
- References
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Summary. Women with histologically confirmed cervical intraepithelial neoplasia grade 2 (CIN 2) were treated in a double blind investigation of treatment with intralesioneal interferon alpha-2b (Tntron a). Before treatment commenced, the existence and the types of human papilloma-virus (HPV) were assessed in [35S] methionine-labelled cervical biopsies by the determination of specific protein markers. Pronounced side effects occurred in all the women treated with interferon and the trial was stopped when it became apparent that there were no obvious beneficial effects. No positive benefits of interferon treatment were detected on either the CIN 2 or on the persistence of HPV types. It is concluded that intralesioneal injection of interferon has no place in the treatment of CIN.