Is large loop excision of the transformation zone (LLETZ) more accurate than colposcopically directed punch biopsy in the diagnosis of cervical intraepithelial neoplasia?

Authors

  • D. T. HOWE,

    Registrar in Obstetrics and Gynaecology , Corresponding author
    1. Royal Hampshire County Hospital, Romsey Road, Winchester, Hants SO22 5DG
      D. T. Howe, Department of Human Reproduction and Obstetrics, Princess Anne Hospital, Southampton SO9 4HA
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  • A. C. VINCENTI

    Consultant Histopathologist
    1. Royal Hampshire County Hospital, Romsey Road, Winchester, Hants SO22 5DG
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D. T. Howe, Department of Human Reproduction and Obstetrics, Princess Anne Hospital, Southampton SO9 4HA

Abstract

Summary. In 100 women with suspected cervical intraepithelial neoplasia (CIN) attending the colposcopy clinic the histological diagnoses made from excision biopsies taken by large loop excision of the transformation zone (LLETZ) were compared with those from colposcopically directed punch biopsies taken concurrently. One unsuspected micro-invasive tumour was found and the diagnosis made by LLETZ was significantly worse than that made by punch biopsy in 24 cases (24%: 95% CI15.6 to 32.4%). LLETZ improves the accuracy of diagnosis of CIN.

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