Placental bed biopsies in placental abruption
Article first published online: 19 AUG 2005
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 99, Issue 8, pages 651–654, August 1992
How to Cite
DOMMISSE, J. and TILTMAN, A. J. (1992), Placental bed biopsies in placental abruption. BJOG: An International Journal of Obstetrics & Gynaecology, 99: 651–654. doi: 10.1111/j.1471-0528.1992.tb13848.x
- Issue published online: 19 AUG 2005
- Article first published online: 19 AUG 2005
- Received 1 July 1991 Accepted 28 February 1992
Objective To investigate structural changes in the uteroplacental blood vessels in association with placental abruption.
Design Prospective descriptive study.
Subjects 18 women with clinical evidence of severe placental abruption delivered by caesarean section.
Interventions Placental bed biopsies were obtained at caesarean section and studied histologically.
Results Six specimens did not include trophoblast in the myometrium and were therefore not representative of the placental bed. Of the 12 representative specimens, seven demonstrated absence of physiological transformation of the utero-placental arteries (four of these were from hypertensive patients). Four biopsies showed abnormal vascular structures deep in the myometrium. One of these abnormal vessels included a fresh plug and extensive surrounding intramyometrial haemorrhage.
Conclusions Vascular malformations in association with placental abruption may be the result of trophoblastic invasion and could be the site of vessel rupture. Further descriptive and comparative studies are needed.