Spontaneous resolution of pre-eclampsia-related thrombocytopenia

Authors

  • RAVI CHANDRAN,

    Clinical Research Fellow, Corresponding author
    1. Nuffield Department of Obstetrics and Gynaecology, University of Oxford John Radcliffe Maternity Hospital Oxford 0X3 9DU, UK
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  • VICENTE SERRA-SERRA,

    Clinical Research Fellow
    1. Nuffield Department of Obstetrics and Gynaecology, University of Oxford John Radcliffe Maternity Hospital Oxford 0X3 9DU, UK
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  • CHRISTOPHER W. G. REDMAN

    Clinical Reader
    1. Nuffield Department of Obstetrics and Gynaecology, University of Oxford John Radcliffe Maternity Hospital Oxford 0X3 9DU, UK
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Dr Ravi Chandran, Lecturer, Department of Obstetrics and Gynaecology, Faculty of Medicine, National University of Malaysia, Jalan Raja Muda, 50300 Kuala Lumpur, Malaysia.

ABSTRACT

Objective To observe the spontaneous resolution of pre-eclampsia-related thrombocytopenia.

Design A retrospective study.

Setting High Risk Pregnancy Unit, John Radcliffe Maternity Hospital, Oxford.

Subjects Thirty women with pre-eclampsia complicated by the HELLP/ELLP syndrome who did not receive any specific treatment for their thrombocytopenia.

Intervention Serial platelet counts throughout labour and the puerperium until the platelet counts returned to levels above 100 × 109/l.

Main outcome measures Time taken from delivery and platelet nadir for platelet counts to return to levels above 100 × 109/1. The rate of recovery from the platelet nadir was measured by the slope of the serial platelet counts plotted against time.

Results The mean time until platelet count exceeded 100 × 109/l was 67 h (SD 25) after delivery and 44 h (SD 17) from the platelet nadir. All women had counts above 100 × 109/1 by 111 h after delivery, and by 88 h after the platelet nadir. Although the time to recovery appeared to depend on the degree of thrombocytopenia, the rate of resolution did not.

Conclusion These data can be used as a guide by clinicians as to the expected time course for postpartum resolution of pre-eclampsia-related thrombocytopenia.

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