The coelomic cavity: an important site of materno-fetal nutrient exchange in the first trimester of pregnancy
Article first published online: 19 AUG 2005
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 100, Issue 8, pages 765–767, August 1993
How to Cite
Campbell, J., Wathen, N., Perry, G., Soneji, S., Sourial, N. and Chard, T. (1993), The coelomic cavity: an important site of materno-fetal nutrient exchange in the first trimester of pregnancy. BJOG: An International Journal of Obstetrics & Gynaecology, 100: 765–767. doi: 10.1111/j.1471-0528.1993.tb14271.x
- Issue published online: 19 AUG 2005
- Article first published online: 19 AUG 2005
- Received 12 November 1992 Accepted 23 March 1993
Objective To measure levels of folate and vitamin B12 in matched samples of amniotic fluid and extraembryonic coelomic fluid from 9 to 12 weeks' gestation.
Design Prospective observational study.
Setting Homerton Hospital, London.
Subjects Twenty-two women with ultrasonographically normal pregnancies before surgical termination.
Methods Transvaginal ultrasound-guided needle aspiration of amniotic fluid and extra-embryonic coelomic fluid was performed. Pure samples of amniotic fluid and extra-embyronic coelomic fluid were obtained from each pregnancy, and folate and vitamin B12 were measured using microbiological assays.
Results Levels of folate and vitamin B12 were higher in extra-embyronic coelomic fluid than in amniotic fluid and maternal serum. Amniotic fluid folate levels were lower than in maternal serum whereas vitamin B12 levels in amniotic fluid were higher than in maternal serum. All differences in concentration were significant (P<0.0005; paired t-Test). Positive correlations were found between the concentrations of folate and vitamin B12 in each fluid. There was a linear correlation between gestational age and amniotic fluid folate levels (r= 0.648; P= 0.001).
Conclusions High concentrations of folate and vitamin B12 in coelomic fluid suggest that the coelomic cavity plays an important role in the materno-fetal exchange of these nutrients.