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Lipid peroxidation in cord blood: the effect of amniotic fluid volume
Article first published online: 19 AUG 2005
DOI: 10.1111/j.1471-0528.1997.tb10937.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 104, Issue 10, pages 1140–1144, October 1997
Additional Information
How to Cite
Wang, C. C. and Rogers, M. S. (1997), Lipid peroxidation in cord blood: the effect of amniotic fluid volume. BJOG: An International Journal of Obstetrics & Gynaecology, 104: 1140–1144. doi: 10.1111/j.1471-0528.1997.tb10937.x
Publication History
- Issue published online: 19 AUG 2005
- Article first published online: 19 AUG 2005
- Received 7 January 1997 Returned for revision 29 April 1997 Accepted 26 June 1997
- Abstract
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Objective To assess the effect of amniotic fluid volume on umbilical cord arterial lipid peroxide levels in relation to intrapartum events.
Design Prospective observational study.
Setting Delivery suite of a teaching hospital, the Chinese University of Hong Kong.
Population Women with singleton, term, cephalic presentation, and an initially normal fetal heart rate tracing.
Methods All pregnancies had amniotic fluid index assessments before and after amniotomy and cord arterial lipid peroxide determination at delivery. Multiple regression analysis.
Main outcome measures Cord arterial malondialdehyde and organic hydroperoxide levels.
Results In 247 cases following amniotomy levels were inversely correlated with intrapartum amniotic fluid index. Amniotic fluid index during labour was an independent determinant of cord arterial lipid peroxide concentration, along with duration of second stage, absence of epidural, presence of tight nuchal cord entanglement and evidence of fetal distress.
Conclusions Oligohydramnios during labour is associated with high levels of lipid peroxidation in the fetus, reflecting an increase in hypoxic cellular damage by free radicals.