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Topical anaesthesia for diagnostic hysteroscopy and endometrial biopsy in postmenopausal women: a randomised placebo-controlled double-blind study

  1. Ettore Cicinelli MD 1,*,
  2. Teodora Didonna MD 1,
  3. Glauco Ambrosi MD 2,
  4. Luca Maria Schönauer MD 1,
  5. Giuseppe Fiore MD 3,
  6. Maria G. Matteo MD 1

Article first published online: 19 AUG 2005

DOI: 10.1111/j.1471-0528.1997.tb11460.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 104, Issue 3, pages 316–319, March 1997

Additional Information

How to Cite

Cicinelli, E., Didonna, T., Ambrosi, G., Schönauer, L. M., Fiore, G. and Matteo, M. G. (1997), Topical anaesthesia for diagnostic hysteroscopy and endometrial biopsy in postmenopausal women: a randomised placebo-controlled double-blind study. BJOG: An International Journal of Obstetrics & Gynaecology, 104: 316–319. doi: 10.1111/j.1471-0528.1997.tb11460.x

Author Information

  1. 1

    Department of Obstetrics and Gynecology, University of Bari, Italy

  2. 2

    Institute of Anatomy, University of Bari, Italy

  3. 3

    Institute of Anesthesiology, University of Bari, Italy

*Correspondence: Dr E. Cicinelli, Department of Obstetrics and Gynecology, University of Bari, Piazza Giulio Cesare, 70124 Ban, Italy.

Publication History

  1. Issue published online: 19 AUG 2005
  2. Article first published online: 19 AUG 2005
  3. Received 20 March 1996 Accepted 10 September 1996

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Objective To evaluate the efficacy and safety of topical anaesthesia in reducing pain and incidence of vasovagal reactions during diagnostic hysteroscopy with endometrial biopsy in postmenopausal women.

Design Randomised placebo-controlled double-blind study. Setting University hospital.

Participants Eighty postmenopausal women undergoing diagnostic hysteroscopy and endometrial biopsy.

Interventions Two millilitres of 2% mepivacaine or saline solution were injected transcervically into the uterine cavity before performing the procedures.

Main outcome measures Evaluation of pain reduction on a visual analogue scale and continuous monitoring of heart rate and blood pressure.

Results The use of the anaesthetic significantly reduced the pain experienced at hysteroscopy and endometrial biopsy. The occurrence of vasovagal reactions was significantly lower in the anaesthetised group.

Conclusions Topical anaesthesia attenuated pain and effectively prevented the occurrence of vasovagal reactions during hysteroscopy and endometrial biopsy in postmenopausal women.

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